丙型和庚型肝炎病毒混合感染母婴传播的研究

Studies on mother-to-infant transmission of hepatitis C virus (HCV) and hepatitis G virus (HGV) co-infection

目的 探索丙型肝炎病毒 (HCV)、庚型肝炎病毒 (HGV)混合感染的母婴传播情况及其影响因素。方法 应用第 3代酶联免疫吸附 (ELISA)法 ,检测 4 5 0 6例孕妇血清HCV抗体 (抗HCV) ,其中 878例检测HGV抗体 (抗HGV) ,用荧光定量PCR(FQ PCR)方法 ,检测孕妇血清HCVRNA、HGVRNA。结果 HCVRNA和HGVRNA均阳性孕妇 10例 ,其所分娩的 11例新生儿中 ,HCVRNA阳性 2例、HGVRNA阳性 2例 ;阴道分娩 3例、急诊剖宫产分娩 1例。母乳喂养 4例 ,孕妇临产前丙氨酸转氨酶 (ALT)升高 3例。结论 孕妇HCV和HGV混合感染并不增加母婴传播率。阴道分娩、孕妇临产前ALT升高及母乳喂养是HCV、HGV混合感染母婴传播的高危因素。

Objective To explore mother-to-infant transmission of hepatitis C virus (HCV) and hepatitis G virus (HGV) co-infection and the influence factors. Methods Antihepatitis C virus (anti-HCV) and anti-hepatitis G virus (anti-HGV) antibodies were detected by third generation enzyme linked immunosorbent assay (ELISA). HCV RNA and HGV RNA were detected by fluorogenic quantitative-PCR (FQ-PCR). Results Totally 4506 common pregnant women were tested positive of serum anti-HCV. In these women, 878 were detected of serum anti-HGV, and 10 of them were found with both HCV RNA and HGV RNA positivities. In their 11 infants, two were positive for HCV RNA, and two were positive for HGV RNA. In these 4 infected infants, three were delivered by birth canal, one was delivered by cesarean section. All four were fed by breast-feeding. Three mother′s ALTs were abnormally high before delivery. Conclusions Hepatitis C and G virus co-infection does not increase the rate of mother-to-infant transmission. Birth canal delivery, breast-feeding and high alanine aminotrans-ferase before delivery are high risk factors for mother-to-infant transmission of HCV and HGV co-infection.