小儿腹股沟斜疝发病危险因素的病例对照研究

A study on the risk factors of indirect inguinal hernia in pediatric patients

目的探讨小儿腹股沟斜疝发生的危险因素。方法采用 1∶2配比的病例对照研究方法 ,对 10 3例腹股沟斜疝患儿和 2 0 6例对照小儿的情况进行问卷调查 ,对相关资料进行单因素及多因素logistic回归分析 ,计算OR(比值比 )值及OR的 95 %CI(可信限 )。 结果小儿腹股沟斜疝发病男性 (93 2 % )多于女性 (6 8% ) (P <0 0 1) ,该病与母亲孕早、中期感冒发热 (OR =12 79,95 %CI:2 90～ 5 6 4 3)、孕期发生先兆流产 (OR =10 0 0 ,95 %CI :1 17～ 85 5 9)、母亲孕前职业性接触有害化学物质 (OR =5 77,95 %CI =1 39～ 2 3 98)、小儿低出生体重 (OR =7 0 5 ,95 %CI =1 4 5～ 33 79)呈正相关。结论男性 ,母亲孕早、中期感冒发热 ,低出生体重 ,孕期发生先兆流产 ,母亲孕前职业性接触有害化学物质是小儿腹股沟斜疝发生的危险因素。

Objective To evaluate the risk factors of pediatric indirect inguinal hernia. Methods A hospital-based case-control study was performed. One hundred and three indirect inguinal hernia cases with two -fold controls (206 cases) were enrolled. Parents were interviewed for their charateristics before and during conception. Unconditional logistic regression model was used for single factor and multivariate analysis to estimate odds ratios and their 95% confidence intervals by SAS 6.12 computer software. Results There were more males than females in the overall identified indirect inguinal hernia(Ratio=93.20%, P <0.01). Indirect inguinal hernia was positively associated with maternal common cold accompanying fever in the first trimester ( OR =12.79,95% CI :(2.90～56.43),neonatal low birth weight( OR =7.05, 95% CI = 1.45～33.79),with threatened abortion in the first and/or second trimester ( OR =10.00,95% CI : 1.17～85.59),and exposure to occupational detrimental chemicals before pregnancy( OR =5.77,95% CI =1.39～23.98). Conclusions The risk factors of indirect inguinal hernia include maternal common cold in the first trimester,male gender,threatened abortion in the first and/or second trimester,maternal exposure to pesticides occupationally,and neonatal low birth weight.