脑梗死后抑郁与负性生活事件相关性研究

The relationship between post-cerebral infarction depression and negtive life events

目的 探讨脑梗死后抑郁与负性生活事件的关系。方法 将脑梗死患者按是否受负性生活事件影响分为 A(n=75 )、B(n=73)两组。采用抑郁自评量表 (SDS)及 Hamilton抑郁量表筛查 ,对两组进行比较分析 ,并观察其治疗效果。结果 A、B两组脑梗死后抑郁的发生率分别为 5 6 %、38.4 % ,两者比较差异显著 (P<0 .0 5 ) ;百忧解可显著改善或治愈脑梗死后抑郁 ,总有效率 6 1.7%。结论 脑梗死后抑郁发生与负性生活事件相关。

Objective To investigate the incidence of post-cerebral infarction depression and its relation to negtive life events and therapy of depression.Methods 148 patients with cerebral infarction were assigned to negtive life event effected group(A group) and non-negtive life event effected group (B group),then assessed by SDS and HAMD in order to analyze the incidence and its relation to negtive life events,compareed the curative effect before and after therapy of fluoxetine.Results The whole incidence of post-cerebral infarction depression is 40.5%. Between A group and B group, the incidence of depression were 56% and 38.4% respectively.The difference was significantly.Fluoxetine was effective to post-cerebral infarction depression.The cure rate was 61.7%.Conclusion The incidence of post-cerebral infarction depression is high and related to negtive life events.Fluoxetine is effective to post-cerebral infarction depression.