肾集合管癌1例报道及文献复习

Collecting duct carcinoma of kidney: one case report and literature review

目的 探讨起源于肾髓质集合管的肾集合管癌 ,分析其病理形态学特征及鉴别诊断。方法 对 1例肾集合管癌进行大体、光镜及免疫组化观察并结合文献分析。结果 镜下肿瘤呈弥漫性或腺管状、乳头状排列。肿瘤纤维性间质反应性增生。免疫表型肿瘤细胞高分子CK、EMA、vimentin、溶菌酶阳性。结论 肾集合管癌是一种起源于肾髓质集合管的罕见的肾肿瘤 ,恶性度高 ,预后差。

Purpose To discuss the histological features and differential diagnosis of collecting duct carcinoma(CDC) which occurred in the medulla of the kidney. Methods One case of CDC was analyzed grossly, light microscopically and immunohistochemically. Results The tumor cells displayed diffuse,tubular, tubular-papillary patterns with a proliferative lyalinizing stroma. Immunohistochemistry, the tumor cells expressed high molecular weight cytokeratin, vimentin, EMA. Conclusions CDC is a rare neoplasm arising from the medullar collecting ducts, and it pursues a more aggressive course with poor prognosis.