肝素介导的老年冠心病患者肝细胞生长因子的释放

Release of hepatocyte growth factor mediated by heparin

目的 :旨在研究普通肝素、低分子肝素对老年冠心病患者血浆肝细胞生长因子 (hepatocytegrowthfactor,HGF)的作用。方法 :5 4名老年冠心病患者随机分成 3组 :静脉普通肝素组、皮下普通肝素组、皮下低分子肝素组 ,3组用药前、后不同时间分别测定血浆HGF及血管内皮细胞生长因子 (vascularendothelialgrowthfactor,VEGF)的浓度。结果 :静脉应用普通肝素后 ,可引起血浆HGF快速、明显的升高 ,用药 10min后达高峰 ,约为用药前的 4 8倍 ;皮下应用肝素后 ,亦可引起血浆HGF快速、明显的升高 ,用药 2～ 3h达高峰 ,与用药前相比分别为 :普通肝素组约为 4倍 ,低分子肝素组约为 5倍。结论 :肝素应用可引起血浆HGF明显升高 ,这证实了肝素抗凝作用以外的生物学作用 ,通过HGF的升高 ,对心血管疾病的修复有积极意义。

Objective: To observe the effects of sodium heparin and low molecular weight heparin on the release of plasma hepatocyte growth factor (HGF) in senior coronary heart disease patients.Methods: Fifty-four senior patients with coronary heart disease were divided into three groups: intravenous sodium heparin, subcutaneous sodium heparin, and subcutaneous low molecular weight heparin (LMWH). Plasma HGF and vascular endothelial growth factor (VEGF) were measured before and after injection.Results: Plasma HGF was increased rapidly and significantly after intravenous injection of sodium heparin, reaching its peak level (about 48 fold) after approximately 10 minutes. Plasma HGF was also increased rapidly and significantly after subcutaneous injection of sodium heparin and LMWH, reaching its peak level (about 4 and 5 fold in sodium heparin and LMWH respectively) after approximately 2-3 hours. Conclusion: The rise of plasma HGF after heparin treatment suggests that heparin has some other biological effects in addition to its anticoagulant property through HGF. By this mechanism, the administration of heparin may be of some importance in the reparation of cardio-vascular diseases.