合欢皂苷及苷元的分离鉴定

Isolation and identification of chemical constituents from Albizia julibrissin Durazz

目的 :研究合欢皮的化学成分。方法 :用色谱法分离合欢皂苷及皂苷元 ,用化学和波谱法鉴定结构。结果 :分离并鉴定了一个三萜皂苷 (1 )和四个三萜皂苷元 (2～ 5 ) ,化合物 1的结构为 3 O [β D 吡喃木糖 (1→ 2 ) β D 吡喃呋糖 (1→ 6 ) β D 葡萄糖 ] 2 1 O [(6S) 2 反式 2羟甲基 6 甲基 6 O β D 吡喃鸡纳糖 2 ,7 辛二烯酸 ] 金合欢酸 2 8 β D 吡喃葡萄糖 (1→ 3) [α L 呋喃阿拉伯糖 (1→ 4 ) ] α L 吡喃鼠李糖 (1→ 2 ) β D 吡喃葡萄糖酯 ,化合物 2 ,3,4 ,5的结构分别为金合欢苷元B ,合欢三萜内酯甲 ,剑叶沙酸内酯 ,金合欢酸甲酯。结论 :化合物 1为首次从合欢皮中分离得到 ,即合欢皂苷Prosapogenin 1 0。

Objective: To study the chemical constituents of the stem bark of Albizia julibrissin Durazz. Methods: Chemical constituents were isolated by the repeated chromatography methods and their structures were identified by spectral analysis. Results: Five compounds were obtained as follows: 3 O [β D xylopyranosyl (1→2) β D fucopyranosyl (1→6) β D glucopyranosyl] 21 O (6S) 2 trans 2 hydroxy methyl 6 methyl 6 O β D quinovopyranosyl 2,7 octadienoyl acacic acid 28 O β D glucopyran osyl (1→3) [α L arabinofuranosyl (1→4)] α L rhamnopyranosyl (1→2) ] β D glucopyranosyl ester (1). acacigenin B (2), julibrotriterpenoidal lactone A (3), machaerinic acid lactone (4), acacic acid methylester (5). Conclusion: Compound 1 was isolated directly from this plant for the first time.