鼻咽癌患者放射性核素骨显像的临床应用

Radionuclide Imaging Application of Skeletal Metastases in Nasopharyngeal Carcinoma

目的 探讨放射性核素骨显像在鼻咽癌患者的临床应用价值。方法 对 15 8例初诊鼻咽癌患者行放射性核素骨显像检查 ,其中 2 9例同时行CT/MRI检查。结果 经放射性核素骨显像检查 ,15 8例患者中先后有 81例骨显像异常 ,临床诊断为骨转移 ,阳性率为 5 1.2 %。N 1～N 3期病例骨转移率为 5 5 .6% ,N 0期为 12 .5 % (P <0 .0 1) ;T1期骨转移率为 41.9% ,T 4期为 5 8.4%(P <0 .0 5 ) ;低分化鳞癌骨转移率为 5 2 .0 % ,中高分化鳞癌为 2 5 .0 % (P <0 .0 5 )。 81例骨显像阳性者中 ,有骨痛症状者 5 2例 (占64 .2 % )。结论 鼻咽癌易发生骨转移 ,放射性核素骨显像检查对鼻咽癌临床分期和治疗有重要意义 。

Objactive To evaluate the effect of radionuclide bone imaging of skeletal metastases in nasopharyngeal carcinoma(NPC).Methods One hundred fifty eight pathients with NPC were examined by radionuclide bone imaging.Results Among them,81 cases were identified as having skeletal metastases.The incidence of bone metastases was about 51.2%.The incidence was 55.6% in N1～3 stages and 12.5% in N0 stage,respectively,P<0.01.The incidence was 41.9% in T1 stage and 58.4% in T4 stage,respectively,P<0.05.The incidence was 52.0% in Ⅲ grade of squamous carcinoma and 25.0% in Ⅰ～Ⅱ grade of squamous carcinoma,respectively,P<0.05.Among 81 patients were identified as heving bone metastases,52 cases(64.2%) complained bone pain.Conclusion Radionuclide bone imaging should be performed in the patients with NPC because it is of importance for evaluation of staging and therapy.