脂微球携载前列腺素E_1对急性心肌梗死后康复及心功能的影响

Effects of liposomal prostaglandin E1 on rehabilitation and cardiac function after acute myocardial infarction

探讨脂微球携载前列腺素E1(Lipo-PGE1)在急性心肌梗死后对心功能和血管内皮功能的影响,从而了解其对急性心肌梗死康复的作用。方法:随机将71例住院急性心肌梗死后3―6个月的患者分为两组,治疗组36例在常规治疗基础上,加用Lipo-PGE110μg/天,静脉滴注,共2周;对照组仅接受常规治疗。分别观察两组在治疗前后心功能、内皮功能指标的变化。结果:两组治疗后心功能有不同程度的改善:两组收缩功能的变化无显著差异,而治疗组在治疗后内皮功能指标、左室舒张功能的改善则具有显著差异(P<0.05)。结论:在常规治疗基础上,加用脂微球携载前列腺素E1更能有效地改善心肌梗死康复期患者的血管内皮功能和左室舒张功能。

Objective:To observe the influence of liposomal prostaglandin E1 on rehabilitation after acute myocardial infarction and the effects on the blood vessel endothelial function and cardiac function. Method:71 patients with AMI after 3 to 6 months were randomly divided into a treatment group(n=36,conventional therapy plus Lipo-PGE110μg daily for 2 weeks)and a control group(n=37,conventional therapy only).Cardiac function and endothelial function(ET?NO?TXB2?6-keto-PGF1α)were measured before and after treatment.Result:Improvement of cardiac function was beneficial in both groups, there was no change in left ventricular systolic function,but it had significant effects on endothelial function and cardiac diastolic function in treatment group(P<0.05).Conclusion:The treatment of liposomal prostaglandin E1 based on conventional therapy can effectively improve the endothelial function and left ventricular diastolic function of patients after acute cardial infarction.