SPECT检测精神分裂症病人的局部脑血流研究(英文)

A Study of Regional Cerebral Blood Flowof Schizophrenics By ^(99m)Tc-ECD Brain SPECT

目的 了解精神分裂症病人的局部脑血流特征 ,探讨局部脑血流与精神病临床症状和疗效的关系。方法 采用PANSS量表评定患者的精神症状 ,应用99mTC -ECD -SPECT技术 ,对 17例从未接受过抗精神病药物治疗的精神分裂症病人 ,在接受治疗前与治疗后测量局部脑血流 ,并与11例正常对照组比较。结果 治疗前病例组右侧额叶与右侧颞叶rCBF低于对照组 (各P <0 .0 5 ) ,治疗后右侧额叶与右侧颞叶rCBF较治疗前明显增加 (各 P <0 .0 5 ) ;治疗前不同脑区rCBF与精神病理症状 (含单个症状评分和因子分 )和疗效均无显著性相关。结论 结果提示精神分裂病人存在右侧额叶与右侧颞叶局部脑功能减退 。

Objective This study was to investigate the characteristic of the regional cerebral blood flow (rCBF) in patients with schizophrenia and the relationship among rCBF ratio, symptoms and efficacy. Methods The rCBF of 17 schizophrenics were measured with SPECT before and after treatment. The psychiatric symptoms of all patients were assessed with PANSS. The results were compared with 11 normal controls. Results Before treatment, the baseline rCBF of right frontal and temporal lobes were lower in schizophrenics than that of in controls. After treatment, rCBF of these two regions in schizophrenics were significantly improved. No significant correlation was found between rCBF in different brain regions and psychopathologic symptoms and efficacy as well. Conclusion The function of the right frontal and temporal lobes decreased in schizophrenia, but there was no significant correlation between rCBF and psychopathological symptoms and efficacy.