草木犀流浸液治疗痔病的实验研究和临床观察

Experimental and Clinical Studies of Melilotus Extract in Treatment of Hemorrhoid

目的 :探讨利用草木犀流浸液治疗痔病的疗效机制。方法 :首先进行动物实验 ,采用大鼠尾部电刺激法 ,评价草木犀流浸液的镇痛作用 ;采用微循环显微分析系统 ,观察肠系膜局部滴加肾上腺素后 ,对照组和治疗组局部微循环血流速度及微循环恢复正常的时间 ,评价草木犀流浸液改善微循环的作用。然后对 83例痔病患者进行临床疗效的观察 ,通过比较治疗前后症状改善情况 ,评价草木犀流浸液对痔病的治疗效果。结果 :实验研究结果显示电刺激引起的痛阈值治疗组较阴性对照组有显著的提高 ,而肠系膜局部滴加肾上腺素后 ,治疗组微循环血流恢复到正常状态的时间较对照组的时间明显缩短 ;临床观察显示用药后 2 d症状积分出现下降 ,7d后则下降更为显著。结论 :草木犀流浸液可以有效地改善局部微循环状态 ,增加血液流量 ,并具有明显的镇痛和抗炎作用 ;临床上可以有效地缓解痔病患者的局部症状 ,且服药越长 ,疗效越显著。

Objective:To study the efficacy of Melilotus Extract in treatment of hemorrhoid.Methods:In experimental study, the antalgic efficacy of the drug was evaluated by stimulating rat tail with electricity. And the efficacy of improving micro-circulation was evaluated by comparing the time of which the local micro-circulation of mesentery got back to normal after dropped epinephrine in the therapeutic and the control group. In clinical study, 83 cases with hemorrhoid received the treatment of Melilotus Extract. Compared with symptoms before treatment, symptomatic relief efficacy was observed at 2 nd day and 7 th day after treatment.Results:The experimental results indicated that the pain threshold of the therapeutic group was significantly higher than that of the control group, while the time of the mesentery micro-circulation recovery was significantly shorter in the therapeutic group than that in the control. The clinical results showed that the symptomatic relief was observed at 2 nd day after treatment, and it was significant at 7 th day.Conclusion:Melilotus Extract can increase the blood stream and improve the state of local micro-circulation, and has the obvious effect of abirritation. In clinic, Melilotus Extract can effectively relieve the local symptoms of hemorrhoid.