小儿原发性肾病综合征血清LPO及全血GSH—PX、Se活性变化及临床意义

Changes in serum LPO and whole blood GSH—PX,Se in children with primary nephrotic syndrome and its clinical significance

本文观察了29例原发性肾病综合征患儿血清 LPO,全血 GSH—PX、Se 活性改变,结果表明:血清 LPO 显著增高,全血 GSH—PX、Se 明显降低。提示该病存在着氧化和抗氧化机制失衡,脂质过氧化反应影响肾病的发生和发展。

The activities of the serum LPO and whole blood GSH—PX,Se were measured in 29 chidren chidren with primary nephrotic syndrome.The results showed that the serum LPOwas much higher than the normal control(P<0.01),while the whole blood GSH—PX, Se were much lower than the normal(P<0.01).It is suggested that the imbalance between oxidationand antioxidation.Lipid peroxide has influence on genesis and development of nephrotic syndrome.