肺心病患者血浆组胺改变的临床意义

Significance of the plasma histamine in patients with cor pulmonale

目的 :探讨肺心病患者血浆组胺 (HA)的变化与临床的关系。方法 :用荧光法测定 6 8例肺心病患者、 2 4例肺炎患者和 4 1例健康者血浆 HA水平。结果 :肺心病急性期 HA水平显著高于肺炎组和健康组 (P<0 .0 1) ,急性期缓解后 HA水平显著下降 (P<0 .0 0 1) ;肺心病急性期并呼吸、循环衰竭和肺性脑病患者 HA水平均高于无并发症患者 (P<0 .0 0 1) ;此外 ,肺心病急性期 HA水平与 Pa O2 呈显著负相关性 (P<0 .0 1)。结论 :本研究提示血浆

Objective:To explore the clinical significance of plasma levels of histamine (HA) in cor pulmonale (CP).Methods:The plasma HA was measured in 68 patients with CP,24 patients with pneumonia and 41 cases of the healthy controls by fluorometry.Results:The plasma levels of HA were significantly higher in the patients with acute phase CP than those in the patients with pneumonia and controls ( P <0 01).The plasma levels of HA after control of CP significantly decreased ( P <0 001).In the CP patients complicated by respiratory failure,heart failure and pulmonale encephalopathy, the plasma levels of HA were significantly higher than those in the patients without complications ( P <0 001).Moreover,there was significantly negative correlation between levels of HA and PaO 2 in the patients with CP during acute phase (r=-0 615, P <0 01).Conclusion:This study indicates that the increase of plasma levels HA may play an important role in CP.Author′s address People Hospital of Xiangzhou District,Zhuhai,Guangdong,519070