摘要
目的了解重庆地区NGU患者支原体感染情况及其药物敏感试验结果。方法对387例支原体培养阳性的非淋菌性尿道(宫颈)炎患者的支原体培养及药敏试验结果进行回顾性分析。结果在支原体感染患者中,以20-40岁患者为主要感染人群,男女比例无明显差别;解脲支原体(Uu)为主要病原体,致病性与菌量无关;在对九种药物进行的药敏试验结果中, 交沙霉素、美满霉素及强力霉素敏感率较高,依次为94.06%、88.89%、86.82%,对克林霉素、阿齐霉素及罗红霉素的耐药率较高。结论对于支原体感染引起的非淋菌性尿道炎,临床医生应当结合药敏试验合理应用抗生素。目前重庆地区支原体感染引起的非淋菌性尿道炎可以首选交沙霉素及半合成四环素类抗生素进行治疗。
Objective: To investigate the prevalence of myco-plasma infections and the sensitivity to antibiotics among patients with nongonococcal urethritis or cer-vicitis (NGU) in Chongqing. Methods: 387 NGU cases with mycoplasma-positive results upon culture were analysed retrospectively. RESULTS: The majority of patients with mycoplasma infections were in the 20-40 year old age group. No significant difference was found between males and females. Ureaplasma urealyticum is the main pathogen of these NGU cases and no clear relationship between its concentration and pathogenic ability was noted. Drug sensitivity was tested against nine antibiotics; the sensitivity rates to josamycim, minocycline and doxycycline were 94.06%, 88.89% and 86.82% respectively, while the resistance rates to lincomycin, ofloxacin, azithromycin and roxthromycin were 74.94%, 42.12%, 41.60% and 40.31% in turn. Conclusions: Josamycin, minocycline and doxycycline could be used as the first choice to treat NGU with mycoplasma infections in Chongqing. It is important to select antibiotics for NGU treatment with mycoplasma infections based on the results of drug sensitivity tests.
