转录因子Oct-4调控下游靶基因及其与胚胎发育全能/多能性的关系

Regulation of Downstream Target Genes of Transcription Factor Oct-4 and Its Relationship with Toti/pluripotency of Embryonic Development

作为一个和胚胎发育全能／多能性相关的转录因子,Oct-4通过多种多样的调控机制激活或抑制不同靶基因的转录,从而在细胞的全能／多能性及未分化状态的调控维持中发挥重要的作用。已知受Oct-4调控的靶基因中,不仅有一些重要的转录因子如Rex-1,而且有一些参与重要细胞活动的基因如Fgf-4,因此对Oct-4调控下游靶基因的研究将有助于对其在分化发育中所起作用的进一步了解,同时对全能／多能性这一发育学基本问题及其调控网络有一个新的认识。

As a transcription factor related to toti/pluripotency of embryonic development, Oct-4 activates or represses different target genes via diverse modulation mechanism, thereby plays important roles in regulation and maintenance of cell toti/pluripotent and undifferentiated state. Among the known target genes regulated by Oct-4, there are not only some important transcription factors, for example Rex-1, but also some genes participate in important cellular activities such as Fgf-4. So researches on regulation of downstream target genes of Oct-4 will help us to find out it's role in differentiation and development, and provide new insights into the understanding of toti/pluripotency and it's regulatory net in development.