细胞微囊化免疫隔离技术在移植医学中的应用

Immunoisolation Technology by Cell Microencapsulation in Transplantation Medicine

作为一种十分有效的免疫隔离技术,细胞微囊化可排除细胞移植中出现的宿主与移植物之间的双向排斥作用,从而使能分泌生物活性物质的细胞在移植后得以存活。目前报道的多种微囊材料中,以海藻酸钠-聚赖氨酸-海藻酸钠的应用最为广泛,可通过提高其生物相容性来减弱免疫排斥反应。细胞微囊化在医学治疗上正在发挥越来越大的作用,特别是基因修饰细胞日益成为研究的焦点。尽管该技术尚需改进,但它在异体和异种组织或细胞移植等方面有着广阔的应用前景。

As an effective immunoisolation technology, cell microencapsulation can overcome the dual repelling interactions between the host and donor cells to keep the transplanted cells excreting bioactive substances. Alginate-polylysine-alginate membrane is the most widely used microencapsulation material that can reduce immune repulsion by improving its biological compatibility. Cell microencapsulation, especially with the transgenic cells is playing more and more important role in medical treatments. Cell microencapsulation will have a promising future in various tissue and cell allograft or xenograft despite the needs of technology improvement.