S100A4基因表达在肿瘤转移中的作用

The Relationship between S100A4 Gene and Metastasis of Tumor Cells

肿瘤转移是细胞恶性的重要标志之一,有许多基因和因子都参与这一过程。对S100A4基因的研究发现,它可参与细胞周期调控、细胞增殖与分化、血管生成、细胞外基质重建等多种生命过程,调控细胞的生长和运动。在某些特定的肿瘤细胞内,它的表达含量的增加可促进肿瘤细胞发生转移,并与癌症的发生具有某些相关性,可能对人类癌症的发生具有预后作用。现就S100A4基因表达与肿瘤转移的关系进行初步的探讨,以期对癌症的临床诊断提供一些参考。

Metastasis is an important malignant character of tumor. Many genes and factors are involved in this process. Former studies found that S100A4 gene could participate in many vital cellular activities, including cell cycle control, cell proliferation and differentiation, angiogenesis, remodeling of the extracellular matrix. In some tumor cells, the expressive up-regulation of protein S100A4 is correlated with metastasis and oncogenesis. This article is written to provide some useful information for the study of the relationship between S100A4 gene and metastasis.