摘要
【目的】探讨糖尿病大鼠视网膜中央动脉(CRA)的血流动力学变化及灯盏花素的防治作用。【方法】用链脲佐菌素(STZ)诱导糖尿病模型后,在第12-13周采用彩色多谱勒对各组视网膜中央动脉(CRA)进行血流参数的测量,包括峰值血流速度(PSV)、舒张期最低流速(EDV)、平均血流速度(MV)、阻力指数(RI)和搏动指数(PI)。【结果】糖尿病组大鼠CRA的血流速度较对照组显著降低(P<0.01),而阻力指数和搏动指数则显著增高(P<0.05)。在灯盏花素治疗组,糖尿病大鼠视网膜血流动力学得到显著改善,与糖尿病组相比CRA的血流速度显著增加(P<0.01),阻力指数和搏动指数显著降低(P<0.05)。【结论】12周的糖尿病大鼠视网膜已开始出现血流灌注不良和血流减少,但灯盏花素能明显改善糖尿病大鼠的视网膜的血流动力学,增加血流量和灌流量。
ObjectiveTo investigate the changes of the retinal blood flow in the diabetic rats by measuring the central retinal artery (CRA) and protective effects of erigeron breviscapus (EB). MethodsAfter the rats were induced diabetes with stroptozotocin, the circulatory parameters of the central retinal artery (CRA) were measured using color Doppler imaging, including peak systolic velocity (PSV), end diastolic velocity (EDV), mean velocity (MV), resistive index (RI), and pulsitive index (PI). ResultsThe blood velocity in CRA of the diabetic rats was significantly lower than that of control (P< 0.01). However, RI and PI in the diabetic rats were significantly higher (P< 0.05). The circulatory parameters in EB-treated diabetic rats were improved significantly. Compared with those in the diabetic rats, the blood velocity in CRA being significantly higher (P< 0.01) and RI and PI being significantly lower (P< 0.05). ConclusionThe decreased blood flow and perfusion of the retina was existed in the 12th week diabetic rat, but erigeron breviscapus can improve the retina hemodynamics and increase the retina blood flow and perfusion.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2004年第6期554-556,597,共4页
Journal of Sun Yat-Sen University:Medical Sciences
基金
广东省社会发展重点攻关项目(2002C30106)
