新生儿超广谱β-内酰胺酶细菌感染及防治效果分析

ANALYSIS OF BACTERIAL INFECTION AND PREVENTIVE EFFECTS OF NEONATAL EXTENDED SPECTRUM β-LACTAMASES

目的 为探讨超广谱β-内酰胺酶(ESBLs)细菌感染耐药情况及防治措施。方法 将2000年4月-2003年4月三年间在我院新生儿病房收治的危重新生儿经细菌培养共59例分成两组,2000年4月-2001年10月为第一组共31例;2001年11月-2003年4月为第二组共28例。结果 第一组细菌培养阳性12例,ESBLs阳性6例;第二组阳性10例,ESBLs阳性仅1例,对未采取防治措施前后两组进行统计分析,P<0.01,差异有显著性。结论 表明加强新生儿病房的消毒隔离制度,对ESBLs感染患儿进行隔离,立即停用三代头孢菌素,根据药敏调整抗生素,对ESBLs感染采取有效防治措施后要可减少耐药菌的发生。

Objective To invertigate theincidence and presention effort of neonatal Extended spectrum bbbbbbbbbb - Lac-tamases bacteria infection. Fifty nine critical neonates admitted to Neonatal Department of our hospital were devided into two groups. The first group included 31 babies, and the second group had 28 patients. Results In first group, there were 6 ESBLs positive cases out of 12 culture positive cases, while in the second group, there were l ESBLs positive case out of 10 positive cases. Statistics analysis showed signif- icantly difference between two groups, P < 0.01. Conclusions The effective methods to reduce produc tion of drug resisted bacteria are: strengthening regulations of sterilizatiem and isolation in neonatal wards; isolating neonatal patients with ESBLs; stopping applications of the third genration cephalosporins; ad-justing antibiotics application according to test of drug sensitivity; adopting effective prevention measures to ESBLs infection.