不同致病菌致老年肺炎血清降钙素原的改变

Change in Serum Procalcitonin in the Aged with Pneumonia Caused by Different Pathogenic Microo Rganism

目的 :评价血清降钙素原 (PCT)在鉴别老年细菌性肺炎与病毒性肺炎方面的预测价值。方法 :对全部 82例老年肺炎患者进行血清降钙素原、C-反应蛋白 (CRP)及外周血白细胞计数 (WBC)检查 ,并比较各指标在细菌及病毒感染中的差异。结果 :若以 PCT≥ 0 .5 ng/ ml为阳性阈值 ,则血清 PCT检测对细菌感染的敏感性为 91.4 % ,特异性为83.3% ,阳性预测值为 93.0 % ,阴性预测值为 80 .0 %。病毒感染组和细菌感染组 PCT有显著性差异 (P<0 .0 1)。结论 :PCT可作为细菌感染诊断的有效指标之一 ,可用于鉴别病毒感染和细菌感染。

Objective:To assess the predictive value of procalcitonin(PCT)in differen tiating bacterial pneumonia from viral pneumonia.Methods:The serum PCT、C reactiv e protein(CRP)and white blood cells(WBC)were determined in 82 old patients with pneumonia.The difference in bacterial and viral pneumonia was compared between each index. Results:Taken serum PCT≥0.5 ng/ml as a threshold ,the sensitivity、specificity、positive predictive value and negative predictive value of the test in diagnosing bacterial infection dis eases were 91.4%、83.3%、93.0%、80.0%,respectively.There were statistical differences in the level of serum PCT between the group of virus infection and the group of bacter ial infection(P<0.01).Conclusion:PCT could be used as an e ffective diagnostic marker for bacterial infection.