期刊文献+

T细胞去除在异基因造血干细胞移植中的应用

下载PDF
导出
摘要 T细胞去除(TCD)对allo-HSCT的疗效具有双重性,既能预防GVHD,又会导致移植排斥、 白血病复发率的升高及免疫重建延迟和EB病毒相关的淋巴增殖性疾病增加,因此限制了它的临床应用。 通过改进TCD技术有望达到既预防GVHD又不影响植人、抗白血病活性及免疫重建的目的。
作者 何祎 韩明哲
出处 《国外医学(输血及血液学分册)》 2004年第6期504-508,共5页 Foreign Medical Sciences(Section of Blood Transfusion and Heanatology)
  • 相关文献

参考文献24

  • 1Martino R, Rovira M, Carreras E, et al. Severe infection after allogeneic peripheral blood stem cell transplantation: a matched pair comparison of unmanipulated and CD34+ cell-selected transplantation. Haematologica, 2001, 86(10): 1075-1086.
  • 2Soiffer RJ, Alyea EP, Hochberg E, et al. Randomized trial of CD8+ T-cell depletion in the prevention of graft-versus-host disease associated with donor lymphocyte infusion. Biol Blood Marrow Transplant, 2002, 8(11): 625-632.
  • 3Drobyski WR, Hessner MJ, Klein JP, et al. T-cell depletion plus salvage immunotherapy with donor leukocyte infusions as a strategy to treat chronic-phase chronic myelogenous leukemia patients undergoing HLA-identical sibling marrow transplantation. Blood,
  • 4Small TN, Papadoppoulos EB, Boulad F, et al. Comparison of immune reconstitution after unrelated and related T cell depleted bone marrow transplantation: Effect of patient age and donor leukocyte infusions. Blood, 1999,93(2): 467-480.
  • 5Sun Q , Pollok KE , Burton RL , et al . Simultaneous ex vivoexpansion of cytomegalovirus and Epstein-Barr virus-specific cytotoxic T lymphocytes using B-lymphoblastoid cell line expressing cytomegalovirus pp65. Blood, 1999, 94 (9): 3242-3250.
  • 6Cavazzana-Calvo M, Bensoussan D, Jabado N, et al. Prevention of EBV-induced B lymphoproliferative disorder by ex vivo marrow B-cell depletion in HLA-phenoidentical T-depleted bone marrow transplantation. Br J Haematol, 1998,103(2): 543-551.
  • 7Hale G, Jacobs P, Wood L, et al. CD52 antibodies for prevention of graft-versus-host disease and graft rejection following transplantation of allogeneic peripheral blood stem cells. Bone Marrow Transplant, 2000,26 (1): 69-76.
  • 8Alyea E, Weller E, Schlossman R, et al. T cell depleted allogeneic bone marrow transplantation followed by donor lymphocyte infusion in patients with multiple myeloma: induction of graft versus myeloma effect. Blood, 2001,98(4): 934-939.
  • 9Marktel S, Magnani Z, Ciceri F, et al. Immunologic potential of donor lymphocytes expressing a suicide gene for early immune reconstitution after hematopoietic T-cell-depleted stem cell transplantation. Blood, 2003, 101 (4): 1290-1298.
  • 10Champlin RE, Passweg JR, Zhang MJ, et al. T-cell depletion of bone marrow transplants for leukemia from donors other than HLA-identical siblings: advantage of T-cell antibodies with narrow specificities. Blood, 2000,95(12): 3996-4003.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部