活性端基聚酸酐的合成及表征

Synthesis and characterization of polyanhydride with active endgroup

采用熔融缩聚法制备端基官能化的聚癸二酸酐.先在常压下合成预聚物,研究了预聚合温度对预聚物聚合度的影响,再在高真空度下进一步熔融缩聚,研究了熔融缩聚升温方式对聚合度的影响.实验结果表明:当预聚反应温度为100℃,反应12h,再在高真空下按一定规律依次升温直到180℃,所得聚酸酐聚合度最高.分别采用FTIR和1HNMR对该酸酐的结构进行了表征.

Polyanhydrides are of particular interests in the area of controlled drug release due to their excellent surface erosion properties.The endgroupfunctionalized poly(sebacic anhydride) was synthesized through twostyles:prepolymerization under normal pressure and further polycondensation in high vacuum.Some effects such as reaction temperature in prepolymerization and temperature increasing schedule were investigated on the degree of polymerization(DP).The results showed that the optimum conditions on DP are 100 ℃ for 12 h in the first step,and then regular increase of temperature to 180 ℃.The polymer obtained was characterized by FTIR and ~1H NMR.