不稳定型心绞痛患者血清hs-CRP、cTnI及CK-MB测定的临床意义

Clinical significance in determination of changes in serum hs-CRP, cTnI and CK-MB in patients with unstable angina

目的:探讨不稳定型心绞痛(UA)患者血清hs—CRP、cTnI及CK-MB测定的临床意义。方法:分别用免疫透射比浊法、夹心ELISA法及免疫抑制法测定63例UA患者和40例稳定型心绞痛(SA)患者血清hs-CRP,cTnI及CK-MB含量。结果:UA患者血清hs-CRP含量为(6.34±1.69)mg/L,与SA组(2.21±0.96)mg/L及健康组(1.10±0.64)mg/L相比较有极显著性差异(P<0.01);UA患者血清cTnl含量为(8.60±8.34)μg/L,与SA组(2.47±1.79)μg/L及对照组(1.95±1.94)μg/L相比较有极显著性差异(P<0.01);3组比较,各组患者血清CK-MB含量差异不显著(P>0.05)。结论:UA患者存在微小心肌损伤,炎症反应是UA一个重要发病因素,cTnI是判断微小心肌损伤特异且敏感的指标,hs-CRP在UA发病机制中有重要意义。

Objective: To explore the clinical significance in the determination of the changes in serum high-sensitivity C-reactive protein (hs-CRP), cardiac troponin I (cTnI) and creatine kinase-MB (CK-MB) in patients with unstable angina (UA). Methods: The serum levels of hs-CRP, TnI and CK-MB were measured by latex scattering immunoassay, sandwich ELISA and enzyme immunoassay for 63 patients with UA and 40 patients with stable angina (SA), respectively. Results: The level of serum hs-CRP was 6.34±1.69 mg/L. As compared with SA group (2.21±0.96 mg/L) and the healthy group (1.10±0.64 mg/L). The serum level of cTnI was 8.60±8.34 μg/ L. As compared with the the SA group (2.47±1.79 μg/L) and the control group (1.94±1.94 μg/L), there were no significant difference in serum CK-MB level (P <0.05). Conclusion: Minor myocardial damage occurs in patients with UA, and inflammatory reaction is an important pathogenic factor. cTnI is a specific and sensitive indicator in the judgment of minor myocardial damage. hs-CRP has its significance in the pathogenesis of UA.