重症肝病患者人工肝治疗前后凝血功能的变化及临床意义

Coagulation function in patients with severe hepatopathy before and after their artificial liver treatment; its changes and clinical significance

目的:观察人工肝支持系统(ALSS)对重症肝病患者凝血功能的疗效。方法:30例重症肝病患者在综合疗法的基础上采用人工肝支持系统治疗,通过治疗前后凝血指标的变化,来判断ALSS治疗重症肝病患者的凝血功能的疗效。结果:治疗后凝血酶原时间(PT),部分活化凝血酶原激酶时间(APTT),凝血酶时间(TT),均有不同程度的缩短(P<0.01),纤维蛋白原(Fib)均有不同程度的改善(P<0.05)。结论:检测ALSS治疗的重症肝病患者的凝血指标有助于临床跟踪疗效。

Objective: To observe the effecacy of artificial liver support system (ALSS) on hemagglutina-tion in patients with severe hepatopathy. Methods: Thirty patients with severe hepatopathy were treated by artificial liver support system on the basis of the general treatment. The effectiveness of coagulation in patients with severe hepatopathy was evaluated according to the changes of blood cells coagulation indexes. Results: Prothrombin time (PT), activated partial prothrombin time (aPPT) and thrombin time (TT) had been shortened in various degrees (P <0.01). Fibrinogen was also improved in various degrees (P<0.05). Conclusion: The measurement of coagulation indexes in patients with severe hepatopathy is useful for clinicians to follow up the effectiveness.