炎症因子在急性冠状动脉综合征预后中的作用

Roles of Mlammatory Factors in the Prognosis of Acute Coronary Syndromes

为探讨C-反应蛋白、纤维蛋白原和肿瘤坏死因子α等炎症因子在急性冠状动脉综合征患者预后中的作用,连续观察了76例急性冠状动脉综合征患者入院时上述指标的变化,随访7～12个月,记录住院期间和出院后新发生的心血管事件。结果发现,随访期内发生心血管事件者C-反应蛋白和纤维蛋白原浓度高于未发生者,而肿瘤坏死因子α在对照组和急性冠状动脉综合征患者的浓度无差别;多因素Logistic回归分析发现,C-反应蛋白和纤维蛋白原是心血管事件的独立危险因素。表明C-反应蛋白和纤维蛋白原是判断急性冠状动脉综合征患者短期预后的有用指标,肿瘤坏死因子α对判断急性冠状动脉综合征患者的预后无价值。

Aim To study the predictive value of inflammatory factors such as C-reactive protein (CRP), fibrinogen and tumor necrosis factor-α (TNF-α) in cardiac events of patients with acute coronary syndromes (ACS). Methods Seventy-six cases of ACS patients were tested of their blood concentrations of CRP, fibrinogen and TNF-α on the day of admission and followed for 7-12 months. Results Concentrations of CRP and fibrinogen in ACS patients were significantly raised compared with the controls, while that of TNF-α showed no difference compared with the controls. Patients who developed cardiac events had higher CRP and fibrinogen levels than those who survived free. Multivariate logistic regression analysis demonstrated CRP and fibrinogen were independent risk factors of ACS. Conclusions CRP and fibrinogen could predict cardiac events in ACS patients in short follow-up period, while TNF-α was of no use in predicting cardiac events in ACS patients.