河南省76株E.Coli O_(157):H_7菌株药物敏感性研究

A study on the Antimicrobial Susceptibility of 76 Escherichia coli E.ColiO_(157):H_7 strains in Henan Province

目的探讨我省E.ColiO157:H7菌株的药物敏感性特点。方法美国疾病预防控制中心和WHO非洲区合作编写的“痢疾和霍乱流行的实验室诊断方法”中介绍的琼脂平板扩散法。结果76株E.ColiO157:H7菌株对庆大霉素、头抱噻甲羧肟、多粘菌素B、氯霉素、氟哌酸、阿莫西林六种抗生素的耐药率均<5%。有毒力菌株与无毒力菌株对庆大霉素、强力霉素、复方新诺明、氯霉素、四环素的耐药率差别有统计学意义,无毒力菌株的耐药率高于有毒力菌株。结论实验结果显示临床治疗可参考使用头抱类、喹诺酮类和氯霉素类抗生素。

Aims :To explore the characteristics of antimicrobial susceptibility of Escherichia Coli O 157 :H 7 in Henan Province.Method:Using the Agar Disk Diffusion Method from Laboratory Methods for the Diagnosis of Epidemic Dysentery and Cholera compiledby Centers for Disease Control and Prevention(CDC),Atlana,Georgia,USA,in cooperation with the World Health Organization Regional Office for Africa,(WHO/AFRO)Harae,Zimbabwe.Result:The resistant rates of76E.Coli O 157 :H 7 strains to Gentamicin、Ceftazidime 、PolymyxinB、Chloramphenicol、Norflxacin and Amoxycillin were all lower than5%.To Gentamlcln、Doxycycline、Sulfamethoxazole timethoprim、Chloramphenicol and Tetracycline,the resistant rates of toxic strains were higher than those of nontoxic sirains,and significant differencese between them were found.Conclusion:Cepholosporins、Quinolones and Chloramphenicols can be considered clinically.