冠心病患者肺炎衣原体感染的调查

Investigation of Chlamydia Pneumoniae Infection in the Patients with Coronary Heart Disease

目的 调查冠心病患者肺炎衣原体感染状况,探讨肺炎衣原体感染与冠心病的关系。方法 应用微量免疫荧光法(MIF)检测192例冠心病患者和37例非冠心病者的双份血清中肺炎衣原体IgG、IgA和IgM抗体滴度。结果 冠心病与非冠心病组肺炎衣原体IgG≥64的比例分别为70.8％和29.7％(P<0.001);IgA≥32所占比例分别为34.9％和16.2％(P=0.026)。冠心病和非冠心病组肺炎衣原体急性感染率分别为9.9％和2.7％(P=0.212),慢性感染率分别为37.5％和21.6％(P=0.064),急性慢性感染合计分别为47.4％和24.3％(P=0.01)。校正冠心病的常见危险因素后IgG≥64为独立影响因素。结论 肺炎衣原体感染有可能是冠心病的诸多危险因素之一。

Purpose: To investigate the relationship between chlamydia pneumoniae infection and coronary artery disease (CAD). Methods: Paired sera from 192 CAD patients and 37 non-CAD controls were studied to detect the titre of IgG, IgA and IgM antibody against chlamydia pneumoniae with microimmunofluorescence(MIF) method. Results: The percentage of CAD patients and non-CAD controls with IgG titre≥64 were 70.8% and 29.7% respectively (P < 0.001), and with IgA≥32 were 34.9% and 16.2% respectively (P = 0.026). Acute infection rates were 9.9% in CAD patients and 2.7% in non-CAD controls (P = 0.212); chronic infection rates were 37.5% and 21.6% (P = 0.064); the total infection rates were 47.4% and 24.3% respectively (P = 0.01). After adjusting common CAD risk factors, IgG titre≥64 was an independent factor. Conclusions: Serologic evidence indicated that chlamydia pneumoniae infection might be one of CAD risk factors.