儿童抽动障碍血浆兴奋性氨基酸水平与行为心理的相关性研究

Study on the plasm level of excitatory amino acid and be behavioral psychology in children with tic disorders

目的 了解抽动障碍患儿血兴奋性氨基酸中谷氨酸 (GLU)、天门冬氨酸 (ASP)水平现状及其与行为心理的相关性。方法 采用高效液相色谱法检测了 4 8例抽动障碍患儿血浆GLU、ASP水平 ,其中暂时性抽动 13例 ,慢性运动性抽动 2 0例 ,抽动 秽语综合征 15例 ;并对其家庭状况和相关行为进行了问卷调查。结果 (1) 4 8例抽动患儿血浆GLU水平明显高于对照组 (P <0 0 1) ;(2 )慢性运动性抽动组和抽动 秽语综合征组患儿血浆GLU、ASP分别与对照组和暂时性抽动组比较 ,结果发现前两组血浆GLU水平明显高于后两组 (P <0 0 5、P <0 0 1) ;各组血浆ASP水平无显著差异 (P >0 0 5 )。 (3)抽动障碍患儿注意缺陷多动障碍、精神紧张、脾气暴躁等行为心理问题较对照组明显增高 (P <0 0 1,P <0 0 5 )。 (4)抽动组血浆兴奋性氨基酸 (EAAS)与多动注意缺陷障碍发生率呈正相关。结论 (1)儿童抽动障碍存在EAA水平变化 ,GLU可能参与抽动障碍的病理生理过程。(2 )

Objective To study the plasma levels of some excitatory amino acid(EAA)such as glutamic acid(GLU) and apparatus acid(ASP)in children with tic disorder(TD) and its relationship with behavioral psychology.Methods High efficiency liquid chromatogram apparatus was applied to test the plasma levels of GLU and ASP in 48 children with TD.Among these children,thirteen cases were transient tic;twenty cases were chronic tic;fifteen cases were complicated with Tourette's Syndrome.We investigated backgrounds of their families and correlative behaviors.Results (1)The plasma levels of GLU in these children were significantly higher than that in normal children as control group(P<0.01).(2)The plasma levels of Glu in sick children with tic disorders and TS were significantly higher than that in children with transient tic (P<0.01).But the plasma levels of ASP in all groups were not significantly different in horizontal comparison(P>0.05).(3)comparing with behavioral psychology,such as attention deficit hyperactivity disorder,psychentonia,hot-tempered and so on,the rates in children with tic disorders were significantly higher than that in normal children(P<0.01,P<0.05).(4)the plasma levels of EAAs in children with tic disorder were positive correlation with incidence rate of tic disorder.Conclusion (1)It is definite that the numerical change of plasma EAAs took place in children with TD.(2)EAAs may be involved with mechanism of tic disorders caused behavioral psychology.