中国正常成年男性前列腺的MRS定量分析

Quantitative Analysis of Normal Prostate with MRS in Chinese Male Adults

目的 用磁共振波谱分析方法定量测量中国正常成年男性前列腺的代谢水平。方法 10例 2 0～ 40岁的成年男性 ,临床无前列腺疾病的征象。在前列腺的中央带和外周带、右侧和左侧的底部、中间和尖部各取一兴趣区 ,共 12个兴趣区 ,测量其 (胆碱 +肌酸 ) /枸椽酸盐 [(Choline +Creatine) /Citrate ,(Cho +Cre) /Cit]的比值。结果 10例正常前列腺中央带各区 (Cho +Cre) /Cit比值之间无显著性差异 (P >0 .0 5 ) ,平均为 0 .75± 0 .3 3 ;外周带各区 (Cho +Cre) /Cit比值之间无显著性差异 (P >0 .0 5 ) ,平均为 0 .5 1± 0 .2 0。前列腺中央带与外周带之间的 (Cho +Cre) /Cit比值有显著性差异 (P <0 .0 1)。结论 正常成年男性前列腺的代谢情况可用MRS来定量评价 ,前列腺中央带和外周带的代谢水平不同。

Objective To evaluate the metabolic level of normal prostate quantitatively with MRS in Chinese male adults. Methods Ten cases with no clinical indication of prostate disease were examined using MRI and MRS. The peripheral and central zone of the prostate were distinctly demonstrated in MRI,the right and left side of the peripheral and central zone were divided into bottom,middle and tip regions of interesting(ROI).Totally 12 ROIs were obtained from each case. The metabolic ratio of (Choline+Creatine)/Citrate, [(Cho+Cre)/Cit] was measured. Results The mean ratios of (Cho+Cre)/Cit in the central zone of different individuals were not significantly different ( P >0.05), the mean value was 0.75±0.33 (mean±standard deviation). The mean ratios of (Cho+Cre)/Cit in the peripheral zone of different individuals were not significantly different ( P >0.05), the mean value was 0.51 ±0.20 (mean±standard deviation). Statistically significant variation in metabolic levels with peripheral zone and central zone was detected ( P <0.05). Conclusion The metabolic levels of normal prostate could be evaluated with MRS quantitatively, there is metabolic difference between the peripheral and central zone.