慢性病毒性肝炎患者贮脂细胞和枯否氏细胞的形态计量研究

Quantitative Studies on Fat-storing Cells and Kupffer Cells in Liver with Chronic Viral Hepatitis

应用免疫组化等方法,对乙型病毒性肝炎患者不同病变阶段,肝组织结蛋白阳性的贮脂细胞和溶菌酶阳性的枯否氏细胞进行了计量研究。结果显示,贮脂细胞数量以中度慢活肝时最多,而在轻微病变和肝硬化时较少;溶菌酶阳性的枯否氏细胞随病变加重而逐渐减少,以中度慢活肝达到最低值。结合电镜及免疫电镜观察,我们认为,贮脂细胞在肝炎肝硬变过程中起重要作用,并且受到枯否氏细胞的调控影响。

Quantitative studies on desmin-positive fatstoring cells(FSC)and lysozyme-positive Kupffer cells(KC)by immuno-histochemistry were carried out.It was foundthat FSC were predominantly increased in chronic active hepatitis(CAH)and there wasonly some peaks of increase in moderate CAH.On the contrary KC were found to bemost abundant in number in mild CAH and chronic persistant hepatitis cases,but KCbecame predominantly decreased during the course of CAH and dropped to the minimumin modernte CAH.It was considered that FSC played n important role in the formationof liver cirrhosis and KC was the major regulatory agency of FSC.