实验性绿脓杆菌角膜溃疡的治疗研究

Experimental Studies on the Treatment of Pseudomonas Aeruginosa Corneal Ulcers

用家兔制作绿脓杆菌性角膜溃疡模型。36只兔随机分成3组,将兔右眼制作成直径6～6.5mm,深度达1/3～1/2角膜厚度中心性角膜溃疡。第一组用抗生素局部治疗,第二组抗生素联合0.5%硫酸锌眼液局部治疗。第三组行紧急治疗性穿透性角膜移植术。实验证实:0.5%硫酸锌眼液能促进角膜溃疡愈合,减少疤痕形成。紧急治疗性角膜移植术是治疗中心性角膜溃疡最有效的办法,该实验为临床应用提供了可靠的动物实验依据。

36 rabbits were divided at random into three groups,each group had 12rabbits.A central ulcer in the right eye of each animal was made with diameter of 6-6.6mm;depth of 1/3-1/2 corneal thickness.First group was treated with topical bacteri-cidals.Second group was treated with topical bactericidals and 0.5% ZnSO_4 eye drops.Third group was treated with emergency keratoplasty of the penetrating ulcer.Theresults demonstrated that 0.5% ZnSO_4 eye drop was able to promote the healing of thecorneal ulcer and reduce the formation of the corneal scarring Emergency keratoplastywas the most effective method in treating the central corneal ulcer.It provided experi-mental foundation for clinical application.