消化性溃疡患者尿中表皮生长因子含量测定的意义

Measurement of the Epidermal Growth Factor in the Urine of Peptic Ulcer Patients

用放射免疫方法对15例消化性溃疡、10例慢性浅表性胃炎和10例健康成人尿中表皮生长因子含量进行了测定。消化性溃疡和浅表性胃炎浓度分别为82.6±9.72μg/L 和129.2±24.2μ/L。消化性溃疡患者尿中表皮生长因子含量显著低于正常对照组(P<0.01),而慢性浅表性胃炎与对照组相比无显著意义(P>0.05)。结果提示表皮生长因子缺乏可能是消化性溃疡的病因之一。

Epidermal growth factor(EGF)was determined by radioimmunologic methodin the urine of 15 peptic ulcer,10 chronic superficial gastritis patients and they were comparedwith 10 normal controls.The results showed that EGF in peptic ulcer,superficial gastritisand controls were 82.6±9.72μg/L,129.2±24.2μg/L and 148.8±19.8μg/L respectively.There is a significant difference between peptic ulcer and normal control(P<0.01),but nodifference between superficial gastritis and normal control(P>0.05).The results heresuggest that the lack of EGF may be one of the pathogenicity of peptic ulcer.