紫锥菊提取物对小鼠单核巨噬细胞系统功能的影响

Effects of Chloroform Extract of Echinacea Purpurea on the Mouse’s Mono Macrophage System

用昆明种小鼠进行碳粒廓清实验 ,观察烟台从加拿大引种的紫锥菊的氯仿提取物对小鼠单核巨噬细胞系统功能的影响 .结果显示 :该提取物在 0 .0 2 5,0 .2 5,2 .5,和 2 2 μg/g四种剂量时 ,对正常昆明种小鼠的单核巨噬细胞系统功能都没有显著影响 ;在 0 .0 2 5μg/ g剂量时 ,对氢化可的松免疫抑制的昆明种小鼠的单核巨噬细胞系统功能有显著影响 ,可使该种小鼠下降了的碳粒廓清能力恢复到正常水平 ,这种作用与 10mg/g剂量的黄芪注射液的作用相当 ;但在 0 .2 5和 2 .5μg/ g剂量时 ,对氢化可的松免疫抑制的昆明种小鼠的单核巨噬细胞系统功能没有显著影响 .说明该引种的紫锥菊有可能成为我国的一种新的药用植物资源 。

Carbon clearance test is carried out in Kunming mice to observe the effect of the chloroform extract of the Yantai introduced from Canada Echinacea purpurea on the function of mono macrophage system. The results show that this extract has no significant effect on the function of the normal Kunming mice's mono macrophage system at the dosages of 0.025, 0.25, 2.5 and 22 μg/g;at the dosage of 0.025 μg/g,it has a significant effect on the function of the hydrocortisone immune inhibited Kunming mice's mono macrophage system,it recovers the mice's reduced carbon clearance ability to the normal level and the effect is comparable to that of the Huang Qi injection at the dosage of 10 mg/g; but at the dosages of 0.25 and 2.5 μg/g,it has no significant effect on the function of the hydrocortisone immune inhibited Kunming mice's mono macrophage system. The results imply that the introduced Echinacea purpurea may become a new medicinal plant resource of this country and the chloroform extract may be developed into an immune restorer.