芒果甙对实验性肝损伤大鼠酶及形态变化影响的研究

Effects of Enzyme and Morphological Change of Mangiferin on Experimental Liver Damage in Rats

利用三种实验模型研究了芒果甙的肝保护作用。三种大鼠肝损伤模型分别由醋氨酚（Ａ－ＰＡＰ），四氯化碳（ＣＣｌ４）和Ｄ－氨基半乳糖（Ｄ－ＧａｌＮ）诱导形成。芒果甙能明显降低三种肝损伤模型大鼠血清的谷丙转氨酶（ＧＰＴ）和谷草转氨酶（ＧＯＴ）水平，病理检查结果显示，芒果甙并能使大鼠肝损伤显著减轻，表明其具有一定的肝保护作用。

The mangiferin was investigated on the hepatoprotective effects in three kinds of models of experimentally-induced liver injuries in rats. The models were induced by acetaminophen, carbon tetrachloride, and D-GalN. The results showed that mangiferin caused significant reduction of the elevated enzyme levels of serum glutamate oxaloacetate transminase, serum glutamate pyruvate transminase in model rats, and alleviated the pathological damages in livers of the model rats. These findings are suggestive of the potent hepatoprotective effects of mangiferin.