硝普钠治疗重症急性胰腺炎家兔血浆SOD的变化

THE CHANGE OF PLASMA SOD WHEN APPLYING SNP IN TREATING ANP OF RABBITS

目的：探讨硝普纳对重症急性胰腺炎治疗作用。方法：采用胰管内注射牛磺胆酸钠溶液的方法建立家兔重症急性胰腺炎（ANP）模型，并用硝普钠进行治疗，动态观察家兔血浆SOD的变化（模型制备后12h、24h、48h）。结果：ANP组血浆SOD明显下降（P＜0．05），而治疗组血浆SOD明显高于非治疗组（P＜0．05）。结论：急性重症胰腺炎早期即出现胰腺微循环障碍，胰腺组织缺血缺氧。SOD明显下降及氧自由基的生成增加参与了ANP的病理过程。硝普钠的早期应用可以改善胰腺微循环障碍，减少氧自由基的生成继而减轻病损、改善预后，为临床重症急性胰腺炎的治疗提供了新途径。

Objective The experiment is to observe the effect of SNP treatment on ANP of rabbits. Method: using ANP model in rabbits, we dynamically observed the changes of the levels of SOD in plasrna at points (12. 24. 48h), as well as the effect of SNP (a sort of No donordrugs) on them. Result: The results showed that the level of SOD in plasma were reduced (P <0. 05) and lasted more than 24 hours in model control group; While the level of SOD in plasma in SNP treatment group were higher (P <0. 05), meanwhile, comparing with the model control group. Conclusions: The results suggest that the pancreatic dricroirculation was obstacled at the early stage of the ANP. The reduction of SOD and increase of OFR Caused the datnage of pancreatic tissues. our study also indicate that applying SNP earller can improve pancreatic dricroirculation, lessen the OFR, reduce the darnage of pancreatictissues in experiment.Therefore, it provided a new method of treatment of clinic ANP.