人脑胶质瘤组织中微血管密度的临床意义

The clinical significance of microvessel density in human glioma

目的 探讨人脑胶质瘤组织中微血管密度 (microvesseldensity ,MVD)的临床意义。方法 应用免疫组织化学技术检测 6 3例人脑胶质瘤组织中CD34的表达情况 ,根据CD34阳性的血管内皮细胞计数来测定肿瘤微血管密度。结果 Ⅲ、Ⅳ级胶质瘤MVD显著高于Ⅰ、Ⅱ级 (P <0 0 5 ) ;术后 18个月内复发和生存期 <3年者MVD显著高于术后 18个月内无复发和生存期≥ 3年者 (P <0 0 1) ;MVD与患者的性别、年龄、肿瘤生长部位无明显相关 (P >0 0 5 )。结论 人脑胶质瘤组织中血管生成与病理分级、术后复发及生存期密切相关 。

Objective: To investigate the clinical significance of microvessel density (MVD) in human glioma Methods: Expression of CD34 in 63 cases of human glioma was examined immunohistochemically MVD was counted by endothelial cells immunostained by anti-CD34 antibody Results: MVD in glioma of grade Ⅲ?Ⅳ was significantly higher than that in grade Ⅰ?Ⅱ(P<0 05) MVD in the patients who had relapsed within 18 months or survived shorter than 3 years was higher than that without recurrence within 18 months or survived longer than those in 3 years (P<0 01) MVD was not related with the patient's sex, age and the site of tumor(P>0 05) Conclusion: MVD correlates positively to histological grade, postoperative recurrence and survival period in human glioma, which can be a significant predicting index of prognosis