Serum total cholesterol level and some cancer mortality:A 7 years follow-up study in 698796 people

目的 为研究血清总胆固醇与全癌、胃癌、肝癌以及肺癌死亡的关系 ,评价血清总胆固醇含量作为这几种癌的预报指标的价值。方法 研究人群是韩国医疗保险公司的投保人 ,且年龄在 4 0岁及 4 0岁以上 ,共有 6 98,796人。 1 992年至 1 993年首先对每一个观察对象进行身体健康检查并调查他们的生活习惯以及疾病既往史。随访开始于 1 994年 1月 1日结束于 2 0 0 0年 1 2月 31日。本研究的主要数据来自健康检查记录以及保险公司的死亡补贴记录。结果 随访期内有 1 1 754人死于癌症 ,其中 2 6 31人死于胃癌 ,2 4 56人死于肝癌 ,2 1 2 9人死于肺癌。血清总胆固醇水平与全癌、肝癌的死亡呈明显的负相关关系并且有统计学意义。血清胆固醇升高 ,全癌和肝癌的死亡率降低 ,不论男性还是女性均是同样的结果。排除随访期前 3年的死亡人数后 ,得到的仍然是这个结果。胆固醇与胃癌之间呈现弱的负相关关系。胆固醇与肺癌间无统计学联系。结论 胆固醇与全癌以及肝癌之间有负的相关关系 ,血清胆固醇含量过低预示死于全癌和肝癌的危险升高。

Objective: To analyze the relationship of serum total cholesterol and mortality from overall cancer, stomach cancer, liver cancer, and lung cancer,and evaluate an importance of serum cholesterol concentrations as predictor of the several cancers in both men and women. Methods: The cohort consisted of the beneficiaries of Korea Medical Insurance Corporation (KMIC) aged 40 and older who had taken the health examination and completed the questionnairenquiring of health habits and past medical history in 1992 or 1993. Numbers of cohort member were 698,796, and they were followed from 1 Jan, 1994 until 31 Dec, 2000. The primary source of the data used in this study were the death benefit record and health examination file of KMIC. Results: There were 11754 deaths from cancer and among them 2631 were stomach cancer, 2456 were liver cancer, 2129 were lung cancer during the follow up period. Meanwhile serum total cholesterol levels were inversely and significantly related to overall cancer and liver cancer mortality in population, in both male and female. Overall cancer and liver cancer mortality decreased with increasing cholesterol levels at the lowest levels in both gender. This effect is still apparent when deaths within three years are excluded in population and male. A weak inverse association between cholesterol and stomach cancer. This is not significant for cholesterol and lung cancer. Conclusion: There is important relation between lower serum cholesterol increased the risk of overall cancer and liver cancer mortality. Low serum cholesterol concentration as predictor of overall cancer and liver cancer is importance in both genders.