人参皂甙Rb1抑制Aβ25-35诱导皮层神经元tau蛋白的过度磷酸化
被引量:2
摘要
目的:探讨人参皂甙Rb1对凝聚态Aβ25-35诱导的胎鼠皮层神经元tau蛋白过度磷酸化的影响及其可能的作用机制。方法通过蛋白免疫印迹法和免疫细胞化学染色法检测胎鼠皮层神经元tau蛋白在Ser396、Ser199/202和Thr231位点的磷酸化水平、总tau蛋白水平和糖原合成酶3B(GSK-3β)的蛋白表达水平。
同被引文献26
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