Therapeutic effect of pranlukast, a cysteinyl leukotriene receptor antagonist, on focal cerebral ischemia in mice

AIM: To determine whether pranlukast (ONO-1078 ), a cysteinyl leukotriene receptor antagonist, possesses therapeutic effect when administered after focal cerebral ischemia in mice. METHODS： Persistent focal cerebral ischemia was induced by middle cerebral artery occlusion, pranlukast and edaravone, a positive control drug, were ip injected 1, 6