重组人肿瘤坏死因子及其与更生霉素联合抗人卵巢癌裸鼠移植瘤作用

THERAPEUTIC EFFECT OF rHTNF ALONE AND IN COMBINATION WITH KSM IN HUMAN OVARIAN CANCER XENOGRAFT IN NUDE MICE

在体外实验的基础上,我们用重组人肿瘤坏死因子(rHTNF)单独或联合更生霉素(KSM)对人卵巢癌裸鼠移植瘤模型进行了8个周期的实验治疗。结果显示,rHTNF可显著地抑制移植瘤生长:rHTNF与KSM联合呈现出较强的协同作用,治疗效果更好。

Based on experiment in vitro, the in vivo anticancer activity of rHTNF alone or in combination with KSM was examined against human ovarian cancer OVCAR transplanted subcutaneously in nude mice. 7 days after transplantation, the animals were divided into four groups of 6 animals each: (A) control; (B) daily ip injections of 3 × 104 U rHTNF and iv injections of 0.2f44g KSM; (C) daily ip injections of 3 × 104 U rHTNF; (D)daily iv injections of 0.2f44g KSM. After 8 weeks of treatment, a statistically significant mean tumor volume difference was found between the control group and groups that received rHTNF or rHTNF plus KSM (P<0.01).