An Unusual Reductive Ring-opening Reaction of Phthalimide with Sodium Hydride in DMF
An Unusual Reductive Ring-opening Reaction of Phthalimide with Sodium Hydride in DMF
摘要
An unusual reductive ring-opening reaction of phthalimide with sodium hydride in anhydrous DMF was observed for the first time. The presumed mechanism was described in detail.
参考文献3
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3[3]Data for compound 6:[α]+30.6 (c 0.85,CHCl3).1H NMR (CDCl3,300 MHz):( 8.00 (m,1 H),7.48-7.12 (m,38 H),4.98~4.55 (m,7 H),4.46~4.36 (m,6 H),4.05～3.92 (m,3 H),3.87 (s,2 H,PhCH2),3.83-3.19 (m,24 H).13C NMR (CDCl3,75 MHz):( 171.2 (C=O),139.2,138.7,138.4,138.2,138.1,137.5,136.7,132.6,132.4,130.5,128.9,128.5,128.4,128.3,128.2,128.2,128.0,127.7,127.5,127.5,127.1,127.0 (aromatic carbon),103.9,102.5 (C-1,C-1'),82.7,81.7,80.1,76.5,75.1,74.8,74.7,73.6,73.5,73.2,73.0,70.6,70.5,70.3,69.0,68.8,68.7,68.4,53.5,52.2,48.3,47.5.MALDI-TOF MS (m/z):C78H87O15N,1238.3 [M+H]+.
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