α_6整合素表达与胃癌生长方式及浸润程度关系的临床意义

<title>inical significance of α6 integrin subunits expression in the growth pattern and depth of invasion of gastric cancer

目的 研究粘附分子α6整合素在胃癌生长方式或浸润程度不同时的表达及其临床意义。方法 用免疫组化法检测55例胃癌。结果 胃癌生长方式不同,浸润程度不同,α6在胃癌原发灶细胞膜上的群体分布极性发生明变。α6在原发灶胃癌细胞膜上的表达程度明显强于邻近正常胃粘膜(P<0.05),在浸润型生长或穿透浆膜时,原发灶中α6呈弱表达(P<0.05)。结论 胃癌原发灶中α6表达的减弱,可能预示着胃癌呈浸润性生长或胃癌可能穿透浆膜等恶性特征,通过检测胃癌原发灶α6的表达,可以客观的评估判断胃癌生长方式或浸润程度,为提高胃癌的诊断和治疗水平打下一定的基础。

<abstract>jective To study the clinical significance of α6 integrin subunits expression in the growth pattern and depth of invasion of gastric cancer. Methods 55 specimens of gastric cencer were investigated by immunohistochemical staining. Results These results showed that differences in the growth pattern and depth of invasion of gastric cancer.α6 was not only distributed in gastric cancer,but also dramatically expressed in primary G·C. . When gastric cancer grows with invading and invades through Serous membrane, the expression of α6 was decreased. Conclusion in gastric tissue α6 decreasing expression may indicate some malignant feature of invasive growth or Serous membrane was invaded. By investigating expression of α6 in gastric cancer may objectively estimate and judge the growth pattern and depth of invasion to promote standard of treatment and diagnosis of gastric cancer.