各类型肝病血清抗-HCV与HCV—RNA的检测及相互关系

DETECTION AND RELATIONAHIP OF ANTI-HCV AND HCV-RNA IN THE SERUM OF VARIOUS LIVER DISEASES

作者对各类型肝病50例(包括急性肝炎22例和慢性肝病28例)血清检测抗-HGV和HCV-RNA,分别采用第二代EIA和PCR法。结果表明:抗-HCV阳性者HCV-RNA阳性率达64％(16/25),在慢性肝病达100％(13/13)。HCV-RNA阳性者抗-HCV阳性率达84.2％。在慢性肝病达92.9％(13/14);而抗-HCV阴性者中HCV-RNA阳性率仅为12％(3/25)。因此两者的符合率较高,说明抗-HCV阳性大多数反映HCV现感染,可以应用于HCV感染的诊断,特别是对于慢性肝病患者。

This paper reports the detection of anti-HCV and HCV-RNA in the serum of 50 cases with various liver diseases, including 22 cases of acute hepatitis and 28 cases of chronic liver diseases. Second generation EIA and PCR were used. The results showed that 16 cases out of 25 cases of anti-HCV positive were HCV-RNA-positive (64%), while it was 100% (13/13) in chronic liver diseases. Anti-HCV-positive ratio in HCV-RNA positive was 84.2% (16/19), and 92.9% in chronic liver diseases. But HCV-RNA positive ratio in anti-HCV-negative was only 12% (3/25). Therefore, they seemed to correspond well. Anti-HCV-positive mainly reflects an existing HCV infection, and it can be used in the diagnosis of HCV infection, especially in p'atients with chronic liver disease.