高生长激素、高泌乳素血症垂体腺瘤的临床病理学研究

PITUITARY ADENOMA ASSOCIATED WITH HYPERSOMATOTROPINEMIA AND HYPERPROLACTINEMIA: A CLINICOPATHOLOGICAL STUDY

采用放射免疫、免疫组化及电镜技术对94例垂体腺瘤进行检查。选择其中36例伴有血清生长激素(GH)和泌乳素(PRL)同时增高者作为研究对象。结果显示,此类腺瘤分4种类型:(1)生长激素与泌乳素细胞混合型腺瘤;(2)嗜酸性干细胞腺瘤;(3)多激素腺瘤;(4)生长激素细胞腺瘤。文中就各型腺瘤的病理和临床特点进行了讨论。

94 cases of pituitary adenomas were examined with radio immunoassay, immunohis-tochemical technique and electron microscopy. Among them, 36 cases associated with hypersomato-tropinemia and hyperprolactinemia were studied. The results showed that they could be classified into four types: (1) mixed growth hormone and prolactin cell adenomas; (2) acidophil stem cell adenomas; (3) plurihormonal adenomas; and (4) growth hormone adenmoas. The pathological and clinical characteristics were discussed.