短程三联疗法对功能性消化不良幽门螺杆菌感染的根除效果

Efficacy of short-term triple therapy for eradication of Helicobacter pylori in the patients with functional dyspepsia

目的 观察短程三联疗法对功能性消化不良 (FD)Helicobacterpylori感染的根除效果。方法 73例H .pylori阳性的FD患者被随机分为A、B 2个治疗组 ,A组 (n =3 6) :奥美拉唑 2 0mgbid ,阿莫西林 1 0bid ,甲硝唑 0 4bid ,疗程 1周 ;B组 (n =3 7) :雷尼替丁 0 15bid ,阿莫西林 1 0bid ,甲硝唑 0 4bid ,疗程 1周 ;疗程结束时记录每组病人症状缓解情况 ,疗程结束后 1个月复查H .py lori。结果 H .pylori根除率分别为A组 5 2 8% (19/ 3 6)、B组 43 2 % (16/ 3 7) ,两组比较无统计学差异 (P >0 0 5 ) ,疗程结束时症状缓解率分别为A组 66 7% (2 4/ 3 6) ,B组 5 1 3 % (19/ 3 7) ,无统计学差异 (P >0 0 5 )。结论 本实验短程三联疗法对FD的H .pylori根除率及症状缓解率过低 ,不适合用于FD的H .

Objective To observe efficacy of short_term triple therapy for eradication of Helicobacter pylori(H.pylori) in the patients with functional dyspepsia.Methods Seventy_three patients were divided randomly into two groups.Group A( n=36 )was treated with omeprazole 20 mg,plus amoxicillin 1 000 mg,and metronidazole 400 mg,po,bid for 1 week;Group B ( n =37) was treated with ranitidine 150 mg,plus amoxicillin 1 000 mg,and metronidazole 400 mg,po,bid for 1 week;One month after anti_ H.pylori therapy, test of Hp was repeated.Results The eradication rates of Group A and Group B were 52 8% and 43 2%,respectively.The results between Group A and Group B showed no significant difference( P >0 05).Conclusion The two kinds of short_time triple therapy is unsuitable to eradication of H.pylori in the patients with functional dyspepsia.