糖尿病患者外周血管病变的内科治疗证据

Medical Treatment Evidence Peripheral Vascular Disease in Diabetic Patients

目的 :评价糖尿病外周血管病变的几种内科治疗手段的疗效。方法 :检索MEDLINE和CochraneDatabase ,以内科治疗糖尿病和非糖尿病的外周血管病变的Meta分析为基础 ,加以综述。结果 :检索到 13项结果 ,共评估了西洛他唑 ,己酮可可碱 ,抗血小板药物 ,运动疗法 ,以及控制危险因素 (吸烟 ,高血脂和高血压等 )对治疗伴或不伴糖尿病的外周血管病变的有效性。结论 :西洛他唑能有效治疗糖尿病及非糖尿病患者的间歇性跛行 ,阿司匹林可能对糖尿病患者的血管病变有一级预防作用 ,己酮可可碱和运动治疗可增加间歇性跛行患者的行走能力 ,控制危险因素 (降血糖 ,降血脂 ,降血压和戒烟 )

Objective:To review the effect of various medical treatments on peripheral vascular disease in diabetic patients. Methods:Search MEDLINE & Cochrane Database to obtain meta-analysis about medical treatment of peripheral vascular disease in diabetics and non-diabetic patients and make a review on the base of them. Results:Thirteen outcomes were found which reviewed the efficacy of the therapy including cilostazol, pentoxifylline, antiplatelet drugs, exercise, risk factor control (smoking cessation, lipid-lowering and hypertension-control) on the peripheral vascular disease in diabetics and non-diabetic patients. Conclusion:Cilostazol was an effective treatment for claudication in diabetics and non-diabetic populations. Aspirin was likely to be effective for the primary prevention of vascular events among diabetic patients. Pentoxifylline and exercise could improve walking ability of patients with intermittent claudication. Further researches were needed to evaluate the effect of risk factor control (glycaemic-control, lipid-lowering, hypertension-control and smoking cessation) on peripheral vascular disease in diabetic patients.