唾液酸化的路易斯-X抗原和PTEN表达与肝细胞癌转移和预后的关系

The Expression of Sialyl Lewis-X and PTEN in Relation to the Metastasis and Prognosis in Hepatocellular Carcinoma

目的 :探讨唾液酸化的路易斯 -X抗原 (sialylLewis -X ,SLeX)和PTEN表达与肝细胞癌 (HCC)转移和预后的关系。方法 :应用免疫组织化学方法 ,检测分析 110例HCC组织中SLexPTEN蛋白表达 ,结合随访资料分析。结果 :在HCC中 ,SLeX和PTEN阳性表达率分别为 39 1%和 33 6 %。SleX阳性表达的HCC转移率高 (P<0 0 5 )、分化程度和患者 >5年生存率低 (P <0 0 5 ) ;PTEN阳性表达的HCC转移率低 (P <0 0 5 )、分化程度和患者 >5年生存率高 (P <0 0 5 )。SLeX表达与PTEN表达呈负相关 (r=- 0 5 7,P <0 0 0 5 )。结论 :SLeX和PTEN表达与HCC转移和患者生存期密切相关 。

Objective:To investigate the correlation of sialyl Lewis-X(SLeX)and PTEN expression with potential of metastasis and prognosis in hepatocellular carcinoma(HCC).Methods:Immunohistochemical method was used to detect SLeX and PTEN expression in 110 cases of HCC.Results:The positive expression rate of SLeX and PTEN in HCC was 39.1% and 33.6% respectively.HCC with positive expression of SLeX had higher metastatic rate(P<0.05)and poorer survival rate in 5 years(P<0.05);HCC with positive PTEN expression had lower metastatic rate(P<0.05)and higher survival rate in 5 years(P<0.05).The expression of SLeX showed a reverse correlation with PTEN expression in HCC(r=-0.57,P<0.005).Conclusion:These data showed PTEN the expression of SLeX and PTEN was closely related to the potential of metastasis and survival rate in HCC.SLeX and PTEN might be the prognostic indicators in HCC.