冠心病、Ⅱ型糖尿病及肾透析患者OX-LDL和AOC分析

Study on Oxidized Low Density Lipoprotein and Anti-oxidized Competence in CHD Patients of DM_2 and HD

目的 :通过对冠心病、Ⅱ型糖尿病及肾透析后患者血清甘油三酯、胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、氧化型低密度脂蛋白胆固醇、载脂蛋白及血液抗氧化状态的分析 ,探讨它们在动脉粥样硬化发生过程中的作用 ,以及氧化型低密度脂蛋白与血液抗氧化状态的关系 ,寻找评价冠心病危险性有效的血液生化指标。方法 :收集经临床确诊的冠心病患者、Ⅱ型糖尿病及肾透析患者各 5 0例及 5 0例无心血管疾病、糖尿病及肾病人群的空腹血清。进行血脂及血液抗氧化状态分析。结果 :冠心病组TG (1 39± 0 34)mmol/L、Chol (4 5 8± 0 92 )mmol/L、HDL -C (1 2 6± 0 36 )mmol/L、LDL -C (2 6 4± 0 4 6 )mmol/L、ApoA1(1 5 9± 0 37)g/L、ApoB10 0 (0 87± 0 2 7)g/L、OX -LDL (0 133± 0 0 3)nmol/L、AOC (14 1± 1 32 )U/ml;Ⅱ型糖尿病组TG (1 4 8± 0 5 1)mmol/L、Chol (4 5 7± 1 10 )mmol/L、HDL -C (1 4 2± 0 4 4 )mmol/L、LDL -C (2 6 9± 0 83)mmol/L、ApoA1(1 6 5± 0 4 7)g/L、ApoB10 0 (0 84± 0 2 1)g/L、OX -LDL (0 12 9± 0 0 2 )nmol/L、AOC (12 8± 2 4 8)U/ml;肾透析后组TG (1 5 5± 0 5 8)mmol/L、Chol (4 6 2± 0 5 8)mmol/L、HDL -C (1 2 7± 0 5 0 )

Objective:To study the serum TG,Chol,HDL-C,LDL-c,Apo,oxidized low density lipoprotein(OX-LDL)and anti-oxidized competence(AOC)in 150 patients with coronary heart disease(CHD)?type 2 diabetes mellitus(DM 2)and during hemodialysis(HD).Methods:150 serums were collected controls with no cardiovascular disease,no diabetes mellitus and no nephrosis.TG,Chol,HDL-C,LDL-C,ApoA 1,ApoB 100,OX-LDL and AOC were detected.Results:In CHD patients mean serum TG,Chol,HDL-C,LDL-C,ApoA 1,ApoB 100,OX-LDL and AOC were 1.39±0.34mmol/L,4.58±0.92mmol/L,1.26±0.36mmol/L,2.64±0.46mmol/L,1.59±0.37g/L,0.87±0.27g/L,0.133±0.03nmol/L,14.1±1.32U/ml.In DM 2 patients mean serum TG,Chol,HDL-C,LDL-C,ApoA 1,ApoB 100,OX-LDL and AOC were 1.48±0.51mmol/L,4.57±1.10mmol/L,1.42±0.44mmol/L,2.69±0.83mmol/L,1.65±0.47g/L,0.84±0.21g/L,0.129±0.02nmol/L,12.8±2.48U/ml.In HD patients mean serum TG,Chol,HDL-C,LDL-C,ApoA 1,ApoB 100,OX-LDL and AOC were 1.55±0.58mmol/L,4.62±0.58mmol/L,1.27±0.50mmol/L,2.81±0.47mmol/L,1.62±0.48g/L,0.87±0.28g/L,0.124±0.02nmol/L,13.7±1.78U/ml respectively.In the control subjects mean serum TG,Chol,HDL-C,LDL-C,ApoA 1,ApoB 100,OX-LDL,G-SH and AOC were 1.23±0.45mmol/L,4.74±0.64mmol/L,1.44±0.25mmol/L,287±0.65mmol/L,1.74±0.24g/L,0.88±0.25g/L,0.101±0.02nmol/L,63.3±15.4mmol/L,19.7±1.50U/ml.The mean serum TG,Chol,HDL-C,LDL-C,ApoA 1 and ApoB 100 were no difference between CHD,DM 2,HD patients with control (P>0.05).OX-LDL was significantly higher in CHD,DM 2,HD patients than in the control (P<0.01),and AOC were significantly lower in the CHD,DM 2,HD patients than in the control (P<0.01).Conclusion:OX-LDL and AOC may be the more sensitive risk marker for evaluating CHD.