病毒性肝炎病例对照调查中二类对照的对比性研究

A COMPARATIVE STUDY ON CASE CONTROL STUDY OF VIRAL HEPATITIS WITH TWO CONTROL PATTERNS

本文报告了医院与普通人群甲、乙型病毒性肝炎病例对照研究中同时使用普通对照与易感者对照进行平行研究的初步结果.医院中甲肝(病例60例,普通对照200例,易感者对照37例)乙肝(病例64例,普通对照200例,易感者对照65例)主要发病因素,人群中甲肝(普通对照时1∶3配比37对,易感者对照时1∶1配比11对)爆发因素,用两种对照方式获得的OR值均无显著差异;除个别因素外,分析效果基本一致.本文对此及其有关因素进行了讨论,初步提示在病毒性肝炎病例对照研究中使用普通对照与易感者对照都是可以的.

The preliminary results of parallel case-control study of viral hepatitis with both general individuals and susceptible individuals as 2 control groups among patients and general population are reported.The number of patients,general controls and susceptible controls of HA Was 60,200 and 37,respectively.That of HB was 64,200 and 65,respectively.37 case-control pairs with 1∶3 matching for general control and 11 pairs with 1∶1 matching for susceptible control were selected in general population among which an outbreak of HA occurred.There were no significant differences between OR values resulted from general control and from susceptible control for risk factors of HA and HB in hospitals and of HA in general population.The anaiysis of results from the two control patterns was similar except for one or two risk factors.The reason and associated factors are discussed and it is preliminarily suggested that in ease-control study of viral hepatitis either geneal control or susceptible control could be used.