乙型肝炎疫苗加强接种的免疫应答反应

STUDY ON IMMUNORESPONSIBILITY TO BOOSTER INJECTION OF HBV VACCINATION

本文对87例HBsAg阳性无症状携带者母亲所生之新生儿应用HBIG和?或乙肝疫苗阻断.在1～5岁期间,每年随访一次.当这些儿童的抗-HBs下降到S/N值(RIA)<10时,随即给予乙肝疫苗加强接种,这样共有166例次接受了加强注射.经加强接种后1年复查共有65例次(36.2%)的儿童重新获得有效水平保护性抗-HBs,平均滴度达30.8.本文还观察到初免的应答效果对加强接种的免疫应答有显著相关性,大多数初免反应良好者,加强接种后抗-HBs滴度高;所需接受的加强接种次数少;有效水平保护性抗-HBs维持时间长.结果显示机体的免疫机制状态不仅决定了初免反应的强弱,也决定了加强接种后的免疫应答状况.初免方法及加强接种的剂量与加强接种的免疫应答强弱间在本组未见有明显相关性.

Eighty seven babies from mothers with positive HBsAg in sera were vaccinated with HBIG and HBV vaccine.When the titer of anti-HBS decreased to below 10(RIA S/N ratio) the booster injection was given during the following up period for 5 years.The level of anti-HBS rerose to more than 10 (RIA S/N ratio) in 39.2% of 166 times of booster injection.The GMT of RIA S/N ratio was from below 10 to 30.8.It was also observed that the immunoresponsibility to booster injection was closely correlated with the primary immunoresponsibility to HBV vaccine.In major of the babies responsed to primary HBV vaccination higher,the titer of anti-HBS after booster injection was higher,the required times of booster injection was fewer,and the effective level of anti-HBS was maintained longer.The study suggested that the status of immunity of organism not only determines the responsibility to the primary HBV vaccination but also determines the immunoresponsibility to the booster injeetion.The method of primary HBV vaccination and the dose of booster injection were not observed to relate to the immunoresponsibility of booster injection