首发抑郁症的近期疗效

Observation of short-term efficacy in the treatment of first-episode depression

目的 探讨首发抑郁症近期疗效及影响因素。方法 应用自制一般资料调查表回顾近7年首次发作抑郁症338例的临床特征和治疗情况。结果 单因素x^2检验显示病程短、无焦虑症状、单用三环类治疗、无需合用抗精神病药物组的疗效好于病程长、存在焦虑症状、非单用三环类治疗、需合用抗精神病药物组(P<0.05～0.01),Logistic回归显示性别、焦虑症状、是否单用三环类及是否合用抗精神药物对疗效的影响最为显著(OR=2.247～6.329)。结论 男性、未伴焦虑症状、不合用抗精神病药物抑郁症患者有较好的疗效,传统的三环类药物有肯定疗效。

Objectives: To investigate the short-term efficacy and related factors of first-episode depression. Method: Using an self-mode general information investigating scale to retrospect the clinical characteristics and treatment response of 338 hospitalized cases with first-episode depression in the past 7 years. Results: With mono-factor X2 analysis we found that patients with short disease course, without anxiety symptoms, with TCA only and without combination of antipsychotics showed better efficacy than those with long disease course, with amiety symptoms, using other drugs besides TCA and with combination of antipsychotics. But sex, anxiety symptoms, mono-TCA therapy and without antipsychotics were the top four interfering factors of efficacy auording to the result of logistic regression analysis (OR=2.247-6.329). Conclusion: Male patients, without anxiety symptoms, and without antipsychotics had better efficacy, traditional TCA had positive therapeutic effect.